![]() 1 ACLF is graded according to prolongation of the INR and number of OFs, and increasing mortality is observed with higher grades. 1 It is frequently associated with one or more extra-hepatic organ failures (OFs), namely kidney, brain, circulation and pulmonary. Future studies are needed to explore the utility of TEG in clinical management of ACLF patients.Īcute on chronic liver failure (ACLF) is a syndrome characterized by acute hepatic failure in patients with an underlying chronic liver disease (CLD). Despite abnormal conventional coagulation tests, TEG parameters in ACLF patients are essentially normal, except reduced maximum amplitude. There was no difference in TEG parameters between different ACLF grades, whereas CCTs were more deranged with increasing grades of ACLF.Ĭonclusion. The mean values of INR in ACLF, AD and HC groups were 2.9 ± 1.4, 1.6 ± 0.4 and 1.1 ± 0.2 P 90% patients. 179 patients were included- 68 ACLF, 53 AD and 58 HC. Healthy subjects were recruited as controls. Consecutive patients were included in the study over 12 months. TEG parameters were assessed in patients with ACLF and AD within 24 h of admission. The aim of the study was to evaluate the TEG parameters in patients with ACLF, chronic liver disease having acute decompensation (AD) and healthy subjects (HC). Thromboelastography (TEG) is a rapid, point-of-care assay, more comprehensive than platelet count and INR as it assesses for platelet adequacy(number and function), coagulation factors and clot retraction. Patients with acute on chronic liver failure (ACLF) have abnormal conventional coagulation tests- platelet count and international normalized ratio (INR). Our journal seeks to publish articles on basic clinical care and translational research focused on preventing rather than treating the complications of end-stage liver disease. Topics covered by AoH include alcoholic liver disease, autoimmune hepatitis, biliary diseases, drug-induced liver injury, genetic liver diseases, NAFLD/NASH and viral hepatitis (HAV, HBV, HCV, HDV, HEV). AoH publishes editorials, opinions, concise reviews, original articles, brief reports, letters to the editor, news from affiliated associations, clinical practice guidelines and summaries of congresses in the field of Hepatology. It is the official journal of the Mexican Association of Hepatology ( AMH), the Latin American Association for the Study of the Liver ( ALEH), the Canadian Association for the Study of the Liver ( CASL) and the Czech Society of Hepatology ( CSH). Annals of Hepatology (AoH) is an international, open access journal published bi-monthly with funds from the Fundación Clínica Médica Sur.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |